Dr. Christopher John Ong

Dr. Christopher John Ong

B.Sc. University of British Columbia, 1988
Ph.D. University of British Columbia, 1996

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Associate Professor, Department of Urologic Sciences, University of British Columbia

 

A key area of focus of Dr. Ong's research program is to understand the molecular mechanisms that govern prostate cancer growth and treatment resistance.  His primary focus has been focused on defining and targeting cell signalling pathways underlying the development and progression of prostate cancer and to develop new therapeutic strategies to improve survival.  Dr. Ong and colleagues have recently discovered a critical secreted cell signaling protein called SEMA3C that drives cancer growth. From this discovery, they developed a novel protein-based medication that disrupts SEMA3C signaling and prevents unhealthy cell growth that leads to prostate cancer, and potentially other cancers.

Dr. Ong is also a co-discoverer/inventor of a novel class of small molecule agonists of the SH2-containing inositol phosphatase, SHIP. This technology was licensed to Aquinox Pharmaceuticals, a UBC spin-off company that Dr. Ong co-founded with his colleagues, Drs. Mui, Andersen and Krystal. Aquinox’s lead drug candidate, Rosiptor, is a small molecule activator of SHIP1 suitable for oral, once daily dosing. Building upon the positive Phase 2 trial results where AQX-1125 demonstrated an ability to improve both pain and urinary symptoms in patients with Interstitial Cystitis Bladder Pain Syndrome (IC/BPS), Rosiptor is now in multicenter Phase 3 clinical trials for treatment of IC/BPS.  Top-line data from the LEADERSHIP 301 trial is anticipated in the third quarter of 2018. 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

PCF BC

Ride to Live 2018 and 50-50 Draw: May 27

The West Coast Motorcycle Ride to Live, raising funds for Prostate Cancer Foundation BC, takes place on Sunday May 27, 2018 in Vancouver, Victoria & the Fraser Valley. Follow the links to join a ride or donate to a rider; or to buy a ticket for a 50/50 draw (BC residents only).

Tournament for Life 2018

2018 Harry Rosen Tournament for Life, June 11

The 2018 Harry Rosen Tournament for Life will be held June 11 at Point Grey Golf & Country Club. The annual event is organized by the UBC & VGH Hospital Foundation to raise funds for the Vancouver Prostate Centre. Click here to visit the Foundation's website for further information.

Employment

Work at the Vancouver Prostate Centre

Thursday, March 8, 2018

Recent publications identify new targets for prostate cancer research

Buttyan and Wang lab groups
Friday, May 4, 2018

Discoveries in Dr. Zoubeidi's lab featured in PCF News

Dr. Amina Zoubeidi
Wednesday, May 9, 2018

MSFHR Health Professional-Investigator award for Dr Black

MSFHR Health Professional-Investigator award for Dr Black
Dr. Peter Black
DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.