Dr. Syam Somasekharan

Dr. Syam Somasekharan

PhD (Biochemistry), Department of Biochemistry, Indian Institute of Science (2007)
Post-Doctoral Fellow (Cell Biology), University of Geneva (2010)
Post-Doctoral Fellow (Proteomics & Cell Biology), University of British Columbia (2015)
Ramanujan Fellow (Cell Biology), Indian Institute of Technology (2016)

 

Team: 
Associate Members
Positions: 

Research Scientist, Vancouver Prostate Centre

 

Dr. Syam Somasekharan joined the Vancouver Prostate Centre as a Research Scientist in 2016. Dr. Somasekharan did his PhD in Biochemistry at the Indian Institute of Science, working on cell signalling mediated by calcium sensitive kinases under cellular stress. In his first post-doctoral fellowship at the University of Geneva with Prof. Jean-Claude Martinou, he investigated the molecular mechanisms of Bax activation in apoptosis process. This work led to a new mechanism discovery of Bax activation during mitochondrial outer membrane permeabilisation (MOMP) [Cell (2010) 142:889-901], now highly cited in the apoptosis field.

In 2010, Dr. Somasekharan joined Dr. Poul Sorensen’s lab as a post-doctoral fellow to study mRNA translation regulatory research in sarcomas and prostate cancer. During this period, Dr. Somasekharan developed a novel mass spec technology called “Click-SILAC” method, with a combination of SILAC (stable isotope labelling of amino acids in cell culture) and click chemistry to identify and quantify newly synthesized proteins [J Proteomics (2012) 77:e1-10]. Click–SILAC has become a popular tool to study protein dynamics in complex biological processes such as signal transduction, cancer biology, and drug discovery. More recently, Dr. Somasekharan has been studying RNA granules in cancer cells, and demonstrated for the first time in the field the involvement of stress granules in tumour invasion and metastasis processes [J Cell Biol (2015) 208:913-29]. Dr. Somasekharan also co-authored several other publications in high impact journals, which include Cell (2013) 153:1064-79; Cancer Cell (2015) 27:682-97; and Proc Natl Acad Sci USA (2014) 111:3032-7. He is also a recipient of several national and international awards including Ramanujan, Ramalingaswamy and Early Career Research Awards from the Government. of India.

Currently Dr. Somasekharan is working on several projects that relate to prostate cancer, including: research on the relationship between stress granule machinery and prostate cancer stem cell destiny; mitochondrial dynamics of prostate cancer cells under varied treatment stresses; and mass spec profiling studies to understand prostate cancer disease progression and vulnerabilities. With sincere motivation and a strong scientific collaborative attitude, Dr. Somasekharan is engaged to fight prostate cancer and open a new page in his research life. 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Robbie Burns celebration

Robbie Burns Gala at the Pan Pacific Vancouver: January 25

The Pan Pacific Vancouver is hosting a celebration of Scotland's most famous poet, Robbie Burns, on January 25.  The event will include fundraising for Prostate Cancer Canada's Plaid for Dad campaign. There will be a traditional itinerary, starting with the official piping in of the guests, with exclusive malt tastings, authentic Scottish cuisine celebrating the haggis and ending the evening with a chorus of Auld Lang Syne. Click here for more information and tickets.

It's a Snow Day poster

It's A Snow Day at Mt. Seymour: March 9

Mt. Seymour is hosting It's A Snow Day, a fundraiser for Prostate Cancer Foundation BC, on Friday March 9. The event will include slope time, a reception, and a silent auction. Click here for more details including how to register, donate and/or sponsor.

 

 

Employment

Work at the Vancouver Prostate Centre

Monday, January 30, 2017

Dr. Amina Zoubeidi leads identification of gene linked to growth of aggressive neuroendocrine prostate cancer (NEPC)

DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.