Blood-based tumour profiling provides less-invasive option for treatment-resistant prostate cancer

Date Posted: 
2017-06-29

The Journal of the National Cancer Institute today published a landmark multi-institutional study describing the first comprehensive comparison of blood-based tumour biopsy versus metastatic tissue biopsy for lethal prostate cancer.

Led by Vancouver Prostate Centre PIs Wyatt, Chi and Gleave, this study showed that a blood-based test can identify all the important driver mutations that are detected in a tissue biopsy. This paves the way for blood-based tumour profiling to replace the need for the metastatic tissue biopsy in prostate cancer patients with treatment-resistant disease.

The work was funded by a Stand Up to Cancer Prostate Cancer Foundation Prostate Dream Team Translational Cancer Research Grant, with additional support provided by Prostate Cancer Canada through the Movember Rising Star in Prostate Cancer research program (AW), the Emil Aaltonen Foundation (MA), and a Terry Fox New Frontiers Program Project.

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer 
Alexander W. Wyatt, Matti Annala, Rahul Aggarwal, Kevin Beja, Felix Feng, Jack Youngren, Adam Foye, Paul Lloyd, Matti Nykter, Tomasz M. Beer, Joshi J. Alumkal, George V. Thomas, Robert E. Reiter, Matthew B. Rettig, Christopher P. Evans, Allen C. Gao, Kim N. Chi, Eric J. Small, Martin E. Gleave

 

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Terry Fox Run: Sunday September 16, 2018

On Sunday September 16, the fundraising Terry Fox walk/run/ride is taking place across Canada.  We are grateful for our  grant support provided by The Terry Fox Foundation and Terry Fox Research Institute continously since 1998 - click here to donate to our team (opens in new window)

 

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18th Annual Pacific Northwest Prostate Cancer Conference: Sat Sept 22, 2018

The 18th Annual Pacific Northwest Prostate Cancer Conference for patients, their families and health care professionals will be held in Vancouver on Saturday September 22, from 8 AM to 4 PM.  Click here for further details and to purchase tickets ($30, includes lunch). (Opens in new window)

 

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Dr. Gleave awarded the 2018 Dr. Chew Wei Memorial Prize in Cancer Research

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