Novel, Highly Specific Therapeutic Target for Neuroendocrine Prostate Cancer Identified by VPC Scientists

Date Posted: 
2015-07-30

Drs. Akamatsu, Wyatt, Gleave and Collins and their team at the VPC have published the result of their ground-breaking work identifying a gene called PEG10 as a novel and highly-specific therapeutic target for neuroendocrine prostate cancer (NEPC) ("The placental gene PEG10 promotes progression of neuroendocrine prostate cancer", Cell Reports, published online).

NEPC is the most common form of prostate cancer that does not rely on the androgen receptor. There are few treatments for NEPC, and due to its fast growth rate and ability to metastasize, patient life expectancy after NEPC diagnosis is short. NEPC can evolve from typical prostate cancer by an adaptive response of the cancer cells while under the stress of treatment.

The team studied this adaptive response and identified key genes that were associated with the malignant aspects of clinical NEPC. One of the genes with increased expression, PEG10, is a gene that is normally only 'switched-on' during the development of the placenta. When PEG10 is aberrantly switched-on again early during NEPC development, it increases proliferation of cancer cells and promotes metastasis. Blocking PEG10 activity in model systems resulted in reduced tumor growth and restricted invasion of the surrounding normal tissue.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Robbie Burns celebration

Robbie Burns Gala at the Pan Pacific Vancouver: January 25

The Pan Pacific Vancouver is hosting a celebration of Scotland's most famous poet, Robbie Burns, on January 25.  The event will include fundraising for Prostate Cancer Canada's Plaid for Dad campaign. There will be a traditional itinerary, starting with the official piping in of the guests, with exclusive malt tastings, authentic Scottish cuisine celebrating the haggis and ending the evening with a chorus of Auld Lang Syne. Click here for more information and tickets.

It's a Snow Day poster

It's A Snow Day at Mt. Seymour: March 9

Mt. Seymour is hosting It's A Snow Day, a fundraiser for Prostate Cancer Foundation BC, on Friday March 9. The event will include slope time, a reception, and a silent auction. Click here for more details including how to register, donate and/or sponsor.

 

 

Employment

Work at the Vancouver Prostate Centre

Monday, January 30, 2017

Dr. Amina Zoubeidi leads identification of gene linked to growth of aggressive neuroendocrine prostate cancer (NEPC)

DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.