Dr. Christopher John Ong

Dr. Christopher John Ong

B.Sc. University of British Columbia, 1988
Ph.D. University of British Columbia, 1996

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Associate Professor, Department of Urologic Sciences, University of British Columbia

 

A key area of focus of Dr. Ong's research program is to understand the molecular mechanisms that govern prostate cancer growth and treatment resistance.  His primary focus has been focused on defining and targeting cell signalling pathways underlying the development and progression of prostate cancer and to develop new therapeutic strategies to improve survival.  Dr. Ong and colleagues have recently discovered a critical secreted cell signaling protein called SEMA3C that drives cancer growth. From this discovery, they developed a novel protein-based medication that disrupts SEMA3C signaling and prevents unhealthy cell growth that leads to prostate cancer, and potentially other cancers.

Dr. Ong is also a co-discoverer/inventor of a novel class of small molecule agonists of the SH2-containing inositol phosphatase, SHIP. This technology was licensed to Aquinox Pharmaceuticals, a UBC spin-off company that Dr. Ong co-founded with his colleagues, Drs. Mui, Andersen and Krystal. Aquinox’s lead drug candidate, Rosiptor, is a small molecule activator of SHIP1 suitable for oral, once daily dosing. Building upon the positive Phase 2 trial results where AQX-1125 demonstrated an ability to improve both pain and urinary symptoms in patients with Interstitial Cystitis Bladder Pain Syndrome (IC/BPS), Rosiptor is now in multicenter Phase 3 clinical trials for treatment of IC/BPS.  Top-line data from the LEADERSHIP 301 trial is anticipated in the third quarter of 2018. 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

PCC Plaid for Dad

Plaid for Dad: June 15, 2018

The VPC is proudly wearing plaid this Friday to raise funds for Prostate Cancer Canada. Click here to visit our team page and donate.

Raymond James Father's Day Walk Run 2018

Father's Day Walk Run: June 17, 2018

The Raymond James Father's Day Walk Run fundraiser for Prostate Cancer Foundation BC takes place Sunday June 17, 2018. Visit the event page for locations and registration. Click here to sponsor the Vancouver Prostate Centre team.

Employment

Work at the Vancouver Prostate Centre

Tuesday, May 29, 2018

Three VPC trainees receive 2018 VCHRI Rising Star Awards

2018 Rising Star Awardees
Wednesday, May 9, 2018

MSFHR Health Professional-Investigator award for Dr Black

Dr. Peter Black
DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.