Expertise & Services

Expertise

Our Functional Genomics core has proven expertise in designing experiments to develop and test pre-clinical treatment strategies using validated models that recapitulate human biology. Model systems are used for validation of novel therapeutics designed to target genetic and molecular aberrations associated with aggressive prostate cancer that are identified using next-generation sequencing in human tumour and circulating free DNA samples.

Services

The Functional Genomics Core provides valuable tools with high clinical relevance for studying the molecular and cellular development and progression of prostate cancer, including:

  • Rapid and comprehensive evaluation of novel small molecules and biologics in preclinical model systems including:
    • Cytotoxicity assays
    • Clonogenic assays
    • Biomarker assays (established or novel)
    • Drug-target and off-target interaction assays
    • Drug-drug interactions
    • in vitro and in vivo tumour cell lines
  • An existing variety of cell lines and models (xenograft and transgenic) including:
    • models for disease progression from androgen dependent to castrate resistant prostate cancer
    • tumors/cells resistant to newly approved AR antagonist enzalutamide 
    • novel first-in-field neuroendocrine trans-differentiation patient-derived xenografts
  • Fully functioning suites for the generation and analysis of xenografts, transgenics and PDXs
  • Liquid nitrogen tanks for storage of patient and PDX tissue
  • Preparation and in vivo application of gene targeting techniques to test pre-clinical efficacy of novel anti-cancer agents, including:
    • antisense oligonucleotides (ASOs, siRNA)
    • novel small molecule or antibody inhibitors
    • novel combination therapies
  • Viral delivery for gain-of-function analyses
  • Antisense/RNAi/CRISPR-Cas9 technology for loss-of-function analyses

The Living Tumour Laboratory

The Living Tumor Lab is a unique and valuable resource, which grows a wide variety of patient-derived cancer tissues, including both low and high-grade solid cancers. This work enables researchers to readily study human cancer tissue in vivo, and develop a variety of transplantable tumour tissue lines that can be used as models for studying cancer growth/progression/metastasis and drug sensitivity.

For more information visit www.livingtumorcentre.com

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

PCC Plaid for Dad

Plaid for Dad: June 15, 2018

The VPC is proudly wearing plaid this Friday to raise funds for Prostate Cancer Canada. Click here to visit our team page and donate.

Raymond James Father's Day Walk Run 2018

Father's Day Walk Run: June 17, 2018

The Raymond James Father's Day Walk Run fundraiser for Prostate Cancer Foundation BC takes place Sunday June 17, 2018. Visit the event page for locations and registration. Click here to sponsor the Vancouver Prostate Centre team.

Employment

Work at the Vancouver Prostate Centre

Tuesday, May 29, 2018

Three VPC trainees receive 2018 VCHRI Rising Star Awards

2018 Rising Star Awardees
Wednesday, May 9, 2018

MSFHR Health Professional-Investigator award for Dr Black

Dr. Peter Black
DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.