Expertise & Services

Expertise

Our Functional Genomics core has proven expertise in designing experiments to develop and test pre-clinical treatment strategies using validated models that recapitulate human biology. Model systems are used for validation of novel therapeutics designed to target genetic and molecular aberrations associated with aggressive prostate cancer that are identified using next-generation sequencing in human tumour and circulating free DNA samples.

Services

The Functional Genomics Core provides valuable tools with high clinical relevance for studying the molecular and cellular development and progression of prostate cancer, including:

  • Rapid and comprehensive evaluation of novel small molecules and biologics in preclinical model systems including:
    • Cytotoxicity assays
    • Clonogenic assays
    • Biomarker assays (established or novel)
    • Drug-target and off-target interaction assays
    • Drug-drug interactions
    • in vitro and in vivo tumour cell lines
  • An existing variety of cell lines and models (xenograft and transgenic) including:
    • models for disease progression from androgen dependent to castrate resistant prostate cancer
    • tumors/cells resistant to newly approved AR antagonist enzalutamide 
    • novel first-in-field neuroendocrine trans-differentiation patient-derived xenografts
  • Fully functioning suites for the generation and analysis of xenografts, transgenics and PDXs
  • Liquid nitrogen tanks for storage of patient and PDX tissue
  • Preparation and in vivo application of gene targeting techniques to test pre-clinical efficacy of novel anti-cancer agents, including:
    • antisense oligonucleotides (ASOs, siRNA)
    • novel small molecule or antibody inhibitors
    • novel combination therapies
  • Viral delivery for gain-of-function analyses
  • Antisense/RNAi/CRISPR-Cas9 technology for loss-of-function analyses

The Living Tumour Laboratory

The Living Tumor Lab is a unique and valuable resource, which grows a wide variety of patient-derived cancer tissues, including both low and high-grade solid cancers. This work enables researchers to readily study human cancer tissue in vivo, and develop a variety of transplantable tumour tissue lines that can be used as models for studying cancer growth/progression/metastasis and drug sensitivity.

For more information visit www.livingtumorcentre.com

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

VPC Terry Fox team 2016

Terry Fox Run: Sunday September 16, 2018

On Sunday September 16, the fundraising Terry Fox walk/run/ride is taking place across Canada.  We are grateful for our  grant support provided by The Terry Fox Foundation and Terry Fox Research Institute continously since 1998 - click here to donate to our team (opens in new window)

 

Vancouver

18th Annual Pacific Northwest Prostate Cancer Conference: Sat Sept 22, 2018

The 18th Annual Pacific Northwest Prostate Cancer Conference for patients, their families and health care professionals will be held in Vancouver on Saturday September 22, from 8 AM to 4 PM.  Click here for further details and to purchase tickets ($30, includes lunch). (Opens in new window)

 

Employment

Work at the Vancouver Prostate Centre

Thursday, July 26, 2018

Dr. Gleave awarded the 2018 Dr. Chew Wei Memorial Prize in Cancer Research

Dr. Gleave
Tuesday, May 29, 2018

Three VPC trainees receive 2018 VCHRI Rising Star Awards

2018 Rising Star Awardees
DNA

Make A Difference

Help the Vancouver Prostate Centre fund research to find better treatments and a cure.