Dr. Alexander Wyatt

Dr. Wyatt

B.Sc. (Biology), University of Nottingham
D.Phil. (Physiology, Anatomy and Genetics), University of Oxford

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Assistant Professor, Department of Urologic Sciences, University of British Columbia

 

Dr. Wyatt is an Assistant Professor in genitourinary cancer genomics. He obtained a DPhil (PhD) in from the University of Oxford in the UK and carried out his postdoctoral training at the Vancouver Prostate Centre in Canada. Dr. Wyatt has a background in basic human genetics, and 8 years of experience in cancer bioinformatics and the analysis of complex datasets. The primary research goals of his laboratory are to dissect the clinical relevance of genomic alterations in metastatic genitourinary cancers, and develop minimally-invasive biomarkers for guiding therapy selection. His team have established a variety of custom next-generation sequencing techniques and novel bioinformatics approaches to interrogate tissue and liquid biopsies from patients enrolled on a series of ongoing clinical trials and protocols.

The Wyatt lab works very closely with Dr. Kim Chi, Dr. Martin Gleave, and other senior medical oncologists and urologists at the Vancouver Prostate Centre and UBC, and together they have recently demonstrated that plasma circulating tumor DNA (ctDNA) is highly representative of metastatic lesions in prostate and bladder cancer, and that somatic alterations detected in ctDNA can help predict therapy resistance or response. The lab currently runs a phase II ‘umbrella trial’ to prospectively test this concept in 500 patients with metastatic prostate cancer. Dr. Wyatt’s team also leverages the serial sampling afforded by ctDNA to study how the prostate tumor genome evolves under the evolutionary pressures of different therapeutic regimens. They are particularly interested in changes to the AR gene, and how DNA repair defective prostate cancer responds to treatment.

Dr. Wyatt has been the recipient of multiple awards including a Coalition to Cure Prostate Cancer Young Investigator Award from the Prostate Cancer Foundation, a Movember Rising Star in Prostate Cancer Research Award from Prostate Cancer Canada and an Early Career Investigator Award from the Canadian Institutes of Health Research.

Learn more about Wyatt lab research at http://blogs.ubc.ca/wyattlab/ (opens in new window)

 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Fathers Day Walk Run 2019

Raymond James Father's Day Walk Run Fundraiser, June 16, 2019

The 21st Annual Raymond James Walk Run fundraiser for Prostate Cancer Foundation BC took place on Sunday June 16, 2019 in various locations across BC. The sponsorship page is still accepting donations;  click here to sponsor our Centre's team (opens in new window).

 

Employment

Work at the Vancouver Prostate Centre

Tuesday, June 11, 2019

Dr. Cox featured in VCHRI News

Dr. Cox and family
Monday, June 3, 2019

Benefits Seen With Apalutamide Plus ADT in Metastatic Castration-Sensitive Prostate Cancer

Dr. Chi