Dr. Alexander Wyatt

Dr. Wyatt

B.Sc. (Biology), University of Nottingham
D.Phil. (Physiology, Anatomy and Genetics), University of Oxford

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Assistant Professor, Department of Urologic Sciences, University of British Columbia

 

Dr. Wyatt is an Assistant Professor in genitourinary cancer genomics. He obtained a DPhil (PhD) in from the University of Oxford in the UK and carried out his postdoctoral training at the Vancouver Prostate Centre in Canada. Dr. Wyatt has a background in basic human genetics, and 8 years of experience in cancer bioinformatics and the analysis of complex datasets. The primary research goals of his laboratory are to dissect the clinical relevance of genomic alterations in metastatic genitourinary cancers, and develop minimally-invasive biomarkers for guiding therapy selection. His team have established a variety of custom next-generation sequencing techniques and novel bioinformatics approaches to interrogate tissue and liquid biopsies from patients enrolled on a series of ongoing clinical trials and protocols.

The Wyatt lab works very closely with Dr. Kim Chi, Dr. Martin Gleave, and other senior medical oncologists and urologists at the Vancouver Prostate Centre and UBC, and together they have recently demonstrated that plasma circulating tumor DNA (ctDNA) is highly representative of metastatic lesions in prostate and bladder cancer, and that somatic alterations detected in ctDNA can help predict therapy resistance or response. The lab currently runs a phase II ‘umbrella trial’ to prospectively test this concept in 500 patients with metastatic prostate cancer. Dr. Wyatt’s team also leverages the serial sampling afforded by ctDNA to study how the prostate tumor genome evolves under the evolutionary pressures of different therapeutic regimens. They are particularly interested in changes to the AR gene, and how DNA repair defective prostate cancer responds to treatment.

Dr. Wyatt has been the recipient of multiple awards including a Coalition to Cure Prostate Cancer Young Investigator Award from the Prostate Cancer Foundation, a Movember Rising Star in Prostate Cancer Research Award from Prostate Cancer Canada and an Early Career Investigator Award from the Canadian Institutes of Health Research.

Learn more about Wyatt lab research at http://blogs.ubc.ca/wyattlab/ (opens in new window)

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

10th Anniversary Ride to Live

West Coast Motorcycle Ride To Live: May 26th

The 10th Anniversary West Coast Motorcycle Ride to Live is taking place in Vancouver and the Fraser Valley on May 26 (Victoria date to be finalized), with details on the event and how to register on the event website.  This fundraiser for Prostate Cancer Foundation BC includes a 50/50 raffle open to all BC residents over age 19.

Step  Up Challenge 2019

Step Up Challenge Vancouver - March 10, 2019

Donations are still being accepted for Prostate Cancer Canada's Step Up Challenge fundraiser, which took place on Sunday March 10.   Click here to donate to The Vancouver Prostate Centre team

Employment

Work at the Vancouver Prostate Centre

Monday, April 1, 2019

VPC's translational research profiled in UBC Faculty of Medicine News

Dr. Gleave at the VPC
Wednesday, April 10, 2019

Dr. Dong interviewed for Science in the City Publication of the Week

Dr. Xuesen Dong