Dr. Alexander Wyatt

Dr. Wyatt

B.Sc. (Biology), University of Nottingham
D.Phil. (Physiology, Anatomy and Genetics), University of Oxford

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Scientist, Michael Smith Genome Sciences Centre, BC Cancer
Assistant Professor, Department of Urologic Sciences, University of British Columbia

 

Dr. Wyatt is an Assistant Professor in genitourinary cancer genomics. He obtained a DPhil (PhD) in from the University of Oxford in the UK and carried out his postdoctoral training at the Vancouver Prostate Centre in Canada. Dr. Wyatt has a background in basic human genetics, and 8 years of experience in cancer bioinformatics and the analysis of complex datasets. The primary research goals of his laboratory are to dissect the clinical relevance of genomic alterations in metastatic genitourinary cancers, and develop minimally-invasive biomarkers for guiding therapy selection. His team have established a variety of custom next-generation sequencing techniques and novel bioinformatics approaches to interrogate tissue and liquid biopsies from patients enrolled on a series of ongoing clinical trials and protocols.

The Wyatt lab works very closely with Dr. Kim Chi, Dr. Martin Gleave, and other senior medical oncologists and urologists at the Vancouver Prostate Centre and UBC, and together they have recently demonstrated that plasma circulating tumor DNA (ctDNA) is highly representative of metastatic lesions in prostate and bladder cancer, and that somatic alterations detected in ctDNA can help predict therapy resistance or response. The lab currently runs a phase II ‘umbrella trial’ to prospectively test this concept in 500 patients with metastatic prostate cancer. Dr. Wyatt’s team also leverages the serial sampling afforded by ctDNA to study how the prostate tumor genome evolves under the evolutionary pressures of different therapeutic regimens. They are particularly interested in changes to the AR gene, and how DNA repair defective prostate cancer responds to treatment.

Dr. Wyatt has been the recipient of multiple awards including a Coalition to Cure Prostate Cancer Young Investigator Award from the Prostate Cancer Foundation, a Movember Rising Star in Prostate Cancer Research Award from Prostate Cancer Canada and an Early Career Investigator Award from the Canadian Institutes of Health Research.

Learn more about Wyatt lab research at http://blogs.ubc.ca/wyattlab/ (opens in new window)

 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Father's Day Walk-Run Fundraiser - June 20, 2021

The 23rd annual Father's Day Walk-Run takes place on Sunday June 20, as a virtual event.  Please consider donating to or joining our team as we raise funds to enable Prostate Cancer Foundation - BC to continue their funding of prostate cancer research and their support patients and their loved ones

Employment

Work at the Vancouver Prostate Centre

Tuesday, June 15, 2021

Dr. Zoubeidi awarded Canada Research Chair 1 in Cancer Therapy Resistance

Dr. Amina Zoubeidi
Friday, May 21, 2021

Professor Madanlal T. Wasan Memorial Prize in Urologic Sciences

Dr. Kishor Wasan (L) and Professor Madanlal T. Wasan (R)