Dr. Amina Zoubeidi

Dr. Amina Zoubeidi

B.Sc. University Mohamed V, Rabat, Morocco
M.Sc. Université du Québec a Montréal
Ph.D. Université de Montréal
Post-Doc. McGill University
Post-Doc. The Vancouver Prostate Centre

Team: 
Clinical and Research Scientists
Executive Team
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Professor, Department of Urologic Sciences, University of British Columbia
Canada Research Chair in Cancer Therapy Resistance

 

Dr. Zoubeidi’s research program aims at uncovering how androgen receptor activity controls phenotypic plasticity, which has been associated with the clinically relevant problem of drug resistance in prostate cancer (PCa). Her multifaceted program addresses the importance of various signaling pathways in this inherently heterogeneous disease. Importantly, amplification of different signaling pathways may be unique to an individual and their disease; therefore, her research program is designed to identify and understand common signaling nodes responsible for the emergence of resistance to ultimately design the best combination therapy to guide clinical decisions.

As a critical tool in her arsenal to investigate the highly clinically relevant problem of treatment resistance to anti-androgens, the mainstay therapy for advanced PCa, she has developed a unique set of reagents and resources.  These include tumours and cell lines resistant to the newest anti-androgen, Enzalutamide (ENZ), making her highly competitive globally in this field of research. This model recapitulates patient heterogeneity of ENZ treatment; while continued AR activity occurs in CRPC, alternative, AR-independent (or non-driven) phenotypes of disease such as Neuroendocrine PCa (NEPC) or anaplastic PCa are emerging in the clinic.

She has been very successful as a young investigator, establishing national and international collaborations on research projects and grants from the public and private sector. This has resulted in over 100 published papers/abstracts, 6 patent applications, as well as funding as both a principal investigator and co-investigator on grants focused on understanding the molecular mechanisms of advanced PCa.

She has been recognized as an outstanding up-and-coming scientist by the Prostate Cancer Foundation-USA (PCF) and was awarded the prestigious PCF Young Investigator Award in 2010. She was the only Canadian holding this award in 2010 class. As a mentor, she nominated her post-doctoral fellow, Dr. Bishop, for the same award; Dr. Bishop was the only Canadian Awardee in the 2013 competition. Dr. Zoubeidi holds prestigious awards from the Terry Fox and Michael Smith Foundations for Health Research, from which she received funding as a New Investigator and Research Scholar. These highly competitive awards and most recently acquired PCa Canada Movember grant will support her research for a total of 10 years. Recently she was awarded the Faculty of Medicine Distinguished Achievement Award in Overall Excellence - Early Career, University of British Columbia (2014) and Research Teaching Award for Excellence in Basic Science, Department of Urologic Sciences, Faculty of Medicine, University of British Columbia (2014). Moreover, her track record of research excellence is underscored by numerous accolades from the American Association for Cancer Research, the American Urological Association, the Northwest Urological Society and others. She had the honor of being invited to speak at numerous national and international conferences on molecular mechanisms and drug targets of PCa, including AACR and CCRC and as a visiting professor at different Universities. She serves on several grant panel review committees including Prostate Cancer Canada, the Canadian Institute of Health Research and Prostate Cancer Foundation USA. She is a member of the editorial board of Endocrine Related Cancer and ad hoc reviewer for numerous journals including EMBO, Oncogene, and the AACR journals.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Conference Flyer Page 1

Breast & Prostate Cancer half-day virtual conference: Saturday, September 18th, 2021

The What you Need to Know for Your Patients Post Breast & Prostate Cancer Conference, taking place online on Saturday, September 18th, 2021 from 8:00am – 1:30pm, is an accredited virtual half-day conference focusing on screening, treatment, side-effect management & emerging new therapies for breast & prostate cancer patients. Click here for more information and to register. 

Dr. Peter Black, team captain

Terry Fox Run fundraiser: September 19th, 2021

The 41st Annual Terry Fox Run is taking place on Sunday September 19, 2021. If you are able, please consider donating to our team (tax receipts issued), raising funds for the Terry Fox Foundation's ground-breaking cancer research. 

Employment

Work at the Vancouver Prostate Centre

Wednesday, September 8, 2021

Recent publication proposes a potential new therapeutic approach to treatment-resistant prostate cancer

Tuesday, August 3, 2021

Dr. Cherkasov receives 2021 Faculty of Medicine Distinguished Achievement Award

Dr. Cherkasov