Dr. Amina Zoubeidi

Dr. Amina Zoubeidi

B.Sc. University Mohamed V, Rabat, Morocco
M.Sc. Université du Québec a Montréal
Ph.D. Université de Montréal
Post-Doc. McGill University
Post-Doc. The Vancouver Prostate Centre

Team: 
Clinical and Research Scientists
Executive Team
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Professor, Department of Urologic Sciences, University of British Columbia
Canada Research Chair in Cancer Therapy Resistance

 

Dr. Zoubeidi is a Tier 1 Canada Research Chair in Cancer Therapy Resistance. Her research program aims to uncover how standard care of prostate cancer therapy targeting the androgen receptor (AR) induces treatment resistance and controls phenotypic plasticity, which has been associated with the clinically relevant problem of drug resistance in prostate cancer. Importantly, amplification of different signaling pathways may be unique to an individual and their disease; therefore, her research program is designed to identify and understand common signaling nodes responsible for the emergence of resistance to ultimately design the best combination therapy to guide clinical decisions.

Her multifaceted research program addresses:

  • Why is treatment-induced lineage reprogramming biased toward particular lineage?
  • How the change in the chromatin architecture can permit an opportune environment for transcription factors (including the Androgen Receptor) to be “reprogrammed” and, in turn, facilitate tumour cell plasticity and therapy resistance?
  • Does this inherent epigenetic plasticity can be therapeutically re-direct cell fate using epigenetic or transcription factor inhibitors?

She has been successful in establishing national and international collaborations on research projects and grants from the public and private sector. This has resulted in over 112 peer-reviewed manuscripts in Cancer Discovery, Cell, Nature Cell Biology, Nature communications, and other and holds 8 patent applications. She received substantial funding She received substantial funding from national (CIHR, TFRI, PCC) and international (PCF-USA, DOD) agencies totalling over 20M dollars.  She is currently the leader/PI of the recently awarded Terry Fox New Frontiers Program Project on understanding lineage plasticity in treatment resistance.

She has been recognized by the Prostate Cancer Foundation-USA (PCF) and was awarded the prestigious PCF Young Investigator Award and PCF challenge award. She is a Michael Smith Scholar and Terry Fox New Investigator.  Recently she was awarded the Faculty of Medicine Distinguished Achievement Award in Overall Excellence - Early Career, University of British Columbia (2014) and Research Teaching Award for Excellence in Basic Science, Department of Urologic Sciences, Faculty of Medicine, University of British Columbia (2014). Moreover, her track record of research excellence is underscored by numerous accolades from the American Association for Cancer Research, the American Urological Association, the Northwest Urological Society and others. She had the honor of being invited to speak at numerous national and international conferences on molecular mechanisms and drug targets of PCa, including AACR and CCRC and as a visiting professor at different Universities. She serves on several grant panel review committees including Prostate Cancer Canada, the Canadian Institute of Health Research and Prostate Cancer Foundation USA. She is a member of the editorial board of Endocrine Related Cancer and ad hoc reviewer for numerous journals including EMBO, Oncogene, and the AACR journals.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Terry Fox Run fundraiser: September 19th, 2023

The 43nd Annual Terry Fox Run is taking place on Sunday September 19, 2023. If you are able, please consider joining and/or donating to our team (tax receipts issued), raising funds for the Terry Fox Foundation's ground-breaking cancer research

Pars for Prostate fundraiser: September 21, 2023

The Second Annual Pars for Prostate golf fundraiser in support of Prostate Cancer Foundation BC takes place September 21, 2022 at Westwood Plateau Golf Course. Join today to take part in this best ball, shotgun style tournament. Skilled holes, putting contest, draw prizes and more. For information and to register please click here.

Employment

Work at the Vancouver Prostate Centre

Thursday, January 18, 2024

Dr Artem Cherkasov receives world-wide challenge in drug discovery

Dr. Cherkasov
Wednesday, February 21, 2024

Dr. Somasekharan has been granted a $1.12 million USD from the DOD Award