Dr. Christopher John Ong

Dr. Christopher John Ong

B.Sc. University of British Columbia, 1988
Ph.D. University of British Columbia, 1996

Team: 
Clinical and Research Scientists
Positions: 

Senior Research Scientist, Vancouver Prostate Centre
Associate Professor, Department of Urologic Sciences, University of British Columbia

 

A key area of focus of Dr. Ong's research program is to understand the molecular mechanisms that govern prostate cancer growth and treatment resistance.  His primary focus has been focused on defining and targeting cell signalling pathways underlying the development and progression of prostate cancer and to develop new therapeutic strategies to improve survival.  Dr. Ong and colleagues have recently discovered a critical secreted cell signaling protein called SEMA3C that drives cancer growth. From this discovery, they developed a novel protein-based medication that disrupts SEMA3C signaling and prevents unhealthy cell growth that leads to prostate cancer, and potentially other cancers.

Dr. Ong is also a co-discoverer/inventor of a novel class of small molecule agonists of the SH2-containing inositol phosphatase, SHIP. This technology was licensed to Aquinox Pharmaceuticals, a UBC spin-off company that Dr. Ong co-founded with his colleagues, Drs. Mui, Andersen and Krystal. Aquinox’s lead drug candidate, Rosiptor, is a small molecule activator of SHIP1 suitable for oral, once daily dosing. Building upon the positive Phase 2 trial results where AQX-1125 demonstrated an ability to improve both pain and urinary symptoms in patients with Interstitial Cystitis Bladder Pain Syndrome (IC/BPS), Rosiptor is now in multicenter Phase 3 clinical trials for treatment of IC/BPS.  Top-line data from the LEADERSHIP 301 trial is anticipated in the third quarter of 2018. 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

10th Anniversary Ride to Live

West Coast Motorcycle Ride To Live: May 26th

The 10th Anniversary West Coast Motorcycle Ride to Live is taking place in Vancouver and the Fraser Valley on May 26 (Victoria date to be finalized), with details on the event and how to register on the event website.  This fundraiser for Prostate Cancer Foundation BC includes a 50/50 raffle open to all BC residents over age 19.

Step  Up Challenge 2019

Step Up Challenge Vancouver - March 10, 2019

Donations are still being accepted for Prostate Cancer Canada's Step Up Challenge fundraiser, which took place on Sunday March 10.   Click here to donate to The Vancouver Prostate Centre team

Employment

Work at the Vancouver Prostate Centre

Monday, April 1, 2019

VPC's translational research profiled in UBC Faculty of Medicine News

Dr. Gleave at the VPC
Wednesday, April 10, 2019

Dr. Dong interviewed for Science in the City Publication of the Week

Dr. Xuesen Dong