B.Sc. Physical Education, University of British Columbia
Doctor of Medicine, University of British Columbia
Fellow of the Royal College of Surgeons of Canada
Fellow, American College of Surgeons
Order of Canada
Director, Vancouver Prostate Centre
Chief Executive Officer, PC-TRiADD
Distinguished Professor and Head, Department of Urologic Sciences, UBC
BC Leadership Chair in Prostate Cancer Research
Dr Gleave is a Distinguished Professor and Chair of the Department of Urologic Sciences at UBC, and a British Columbia Leadership Chair. He is a clinician-scientist and urologic surgeon, and Co-Founder and Executive Director of the VPC, a UBC and National Centre of Excellence, publishing > 560 papers with >47,000 citations, an H-Index of 111, and attracting >$120M in research funding. He was appointed to the Order of Canada for his leadership role in developing new treatments for prostate cancer and for his research on mechanisms mediating treatment resistance in cancer.
Dr. Gleave's clinical practice focuses on urologic oncology in a multi-disciplinary environment spanning localized and advanced cancers. His research characterizes molecular mechanisms mediating treatment resistance in cancer, focusing on adaptive survival responses that drive acquired treatment resistance, and designing combination co-targeting strategies to create conditional lethality and improve cancer control. He patented several anti-cancer drugs and founded OncoGenex Pharmaceuticals to develop OGX-011 and OGX-427, inhibitors of cytoprotective chaperones clusterin and Hsp27 which progressed to Phase III and Phase II trials world-wide. OncoGenex was awarded Canadian Biotech Company of the Year in 2010. Dr. Gleave also recently co-founded TRiADD and Sustained Therapeutics.
Dr Gleave is the recipient of numerous awards, including the 2018 Dr. Chew Wei Memorial Prize in Cancer Research, the Huggins Medal from the SUO in 2018, the Richard Williams Award from the AUA in 2017, the Barringer Medal from the American Association of GU Surgeons; the Eugene Fuller Award from the American Urological Association in 2013; the Aubrey Tingle Prize from the Michael Smith Foundation for Health Research; and the NCIC William Rawls Award for contributions to cancer control in Canada; He was appointed a Distinguished University Scholar at UBC in 2003 and awarded a BC Leadership Chair in 2005. Dr Gleave was awarded the 2006 BC Biotech Award for Innovation and Achievement, and the 2007 BC Innovation Council Frontiers in Research Award.
Updated February 4, 2020