Dr. Nada Lallous

Dr. Lallous

M.Sc, Structural Biochemistry and Biophysics, University of Strasbourg and Institute of Genetics and Molecular and Cellular Biology (IGBMC), France
Ph.D, Structural Biochemistry and Biophysics, University of Strasbourg and IGBMC, France
Post-Doctoral Fellow, the Spanish National Cancer Research Centre (CNIO)

Team: 
Associate Members
Positions: 

Research Scientist, Vancouver Prostate Centre
Adjunct Professor, Faculty of Medicine, University of British Columbia
 

Dr. Nada Lallous has a strong knowledge in protein handling and characterization and wide expertise in preclinical validation of novel inhibitors against various cancer targets, acquired during her PhD in structural biochemistry and biophysics and subsequent >10 years of international cancer research experience. She has led projects from inception to structural determination using X-ray crystallography, and contributed to 20 structures currently available in the Protein Data Bank.

Dr. Lallous joined the Vancouver Prostate Centre as a post-doctoral fellow in 2012. She was mainly involved in elucidating the function of the Binding Function-3 site (BF3) of the androgen receptor (AR) and showed that inhibitors targeting this co-regulator binding pocket could help in overcoming resistance associated with the traditional treatment of advanced and lethal prostate cancer. She also secured an NIH-SPORE grant from the National Cancer Institute to understand the functionality and drug susceptibility of AR variants identified in patients’ circulating cell free DNA (cfDNA). These resistance-associated AR mutations are critically important for predicting and monitoring the response of patients to therapy and ultimately, for the development of evidence-based precision oncology practices. This latter work has led to five peer-reviewed publications and to successful collaborations with various pharmaceuticals companies.

In 2017, Dr. Lallous was appointed as a Research Scientist at the Vancouver Prostate Centre and an Adjunct Professor, UBC Faculty of Medicine. She helped preparing a successful $23M CFI grant to establish a cutting-edge drug discovery pipeline that incorporate all critical elements of personalized genomics, protein production and structural biology. Currently, Dr. Lallous is the manager of the protein bioengineering and biophysics group at the Vancouver Prostate Centre. She and her team are building a core facility to provide support for scientists in their preclinical drug validation and structural studies.

Click here to visit her LinkedIn profile (opens in new window).

 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Fathers Day Walk Run 2019

Raymond James Father's Day Walk Run Fundraiser, June 16, 2019

The 21st Annual Raymond James Walk Run fundraiser for Prostate Cancer Foundation BC took place on Sunday June 16, 2019 in various locations across BC. The sponsorship page is still accepting donations;  click here to sponsor our Centre's team (opens in new window).

 

Employment

Work at the Vancouver Prostate Centre

Monday, July 8, 2019

Dr. Flannigan to lead clinical trial for scrotal pain treatment

Dr. Flannigan
Monday, June 3, 2019

Benefits Seen With Apalutamide Plus ADT in Metastatic Castration-Sensitive Prostate Cancer

Dr. Chi