M.Sc. Jagiellonian University, Krakow, Poland 1980
Ph.D. Institute of Nuclear Physics, Krakow, Poland, 1989
Research Scientist, Vancouver Prostate Centre
Associate Director, UBC Magnetic Resonance Imaging Research Centre
Associate Professor of Urologic Sciences, Faculty of Medicine, UBC
Assistant Professor of Radiology, Faculty of Medicine, UBC
Associate Member, Department of Physics and Astronomy, UBC
Dr. Kozlowski’s main research interest is in the application of Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) technology in prostate cancer research and diagnosis. There are essentially two components to this program: basic research in biology and physiology of prostate cancer using an MR animal system and various tumour models of prostate cancer, and research in the application of MR technology to clinical diagnosis of prostate cancer.
Dr. Kozlowski is developing and applying MRI/MRS technology to study tumour microenvironment (i.e. tumour blood flow, architecture of the tumour vasculature, tumour tissue oxygen tension, tumour hypoxia, pH etc.) and its dependence on the tumour’s hormonal status in animal models of prostate cancer. His current research projects include vessel size imaging with MRI, measurements of tumour hypoxia with EF5 using 19F NMR, and, in collaboration with researchers from BCCA and TRIUMF, correlation between MRI and PET in studying tumour microenvironment. This part of his research is funded by NSERC. Dr. Kozlowski is also developing MRI techniques to study rat models of Spinal Cord Injury (CSI). His particular interest is in the development of a non-invasive MRI-based technique for monitoring changes in myelin in rat spinal cord following injury. This part of his research is funded by CIHR.
Dr. Kozlowski is also developing a novel MRI-based diagnostic technique for prostate cancer. The technique uses a combination of Diffusion MRI and Contrast Enhanced Dynamic MRI to diagnose and stage prostate cancer. The study, funded by the CIHR is conducted using a clinical MRI scanner at Vancouver General Hospital and a research 3T MRI scanner at the UBC MRI Research Centre. The results obtained thus far have shown that the combination of Diffusion MRI and CED MRI provide higher diagnostic sensitivity than each technique alone. More data is being acquired to test whether the novel technique can accurately measure the tumour size and histological grade.