Dr. Poul HB Sorensen

Dr. Poul HB Sorensen

PhD, Biochemistry, University of British Columbia, 1990
MD, University of British Columbia, 1984
Fellow of the Royal Society of Canadian (FRSC)

Team: 
Clinical and Research Scientists
Positions: 

Johal Chair in Childhood Cancer Research
Professor, Department of Pathology, University of British Columbia
Distinguished Scientist, BC Cancer Research Centre
Senior Research Scientist (Honorary), Vancouver Prostate Centre

 

Dr. Poul Sorensen is a molecular pathologist and cancer biologist specializing in the genetics and biology of pediatric cancers. Dr. Sorensen holds the Johal Endowed Chair in Childhood Cancer Research at the University of British Columbia (UBC), and is Professor of Pathology at UBC. Dr. Sorensen is a founding member of the AACR Pediatric Cancer Working Group. He is a principal investigator on the recently awarded Stand Up 2 Cancer Pediatric Cancer Dream Team grant focused on immunotherapeutic approaches to targeting high-risk childhood cancers. His group runs several major components of this prestigious award, including the Pathology Core.

Dr. Sorensen’s laboratory, located at the BC Cancer Research Centre, focuses on using both genetic approaches (such as next-generation sequencing) and biochemical methods (e.g. proteomics) to identify deregulated signaling cascades in childhood cancer cells. His group has discovered many novel translocation associated alterations in childhood cancer (e.g. Knezevich et al, Nat Genet, 1998, Tognon et al, Cancer Cell, 2002). Moreover, the group has extensive renown in utilizing genetic findings as a means to characterize relevant cancer biology (e.g. Evdokimova et al, Cancer Cell, 2009, Mendoza-Naranjo et al, EMBO Mol Med, 2013, Leprivier et al, Cell, 2013, Daugaard et al, Nat Comm, 2013, Somasekharan et al, J Cell Biol, 2015, and El-Naggar et al, Cancer Cell, 2015).

Current work is focused on how cancer cells respond to acute stress. The overarching hypothesis is that adaptation to such stresses through altered mRNA translation and protein synthesis leads to tumour cell clonal selection and metastasis. The group therefore utilizes a variety of proteomic and other techniques to probe the “translatome” of stressed tumour cells to identify new targets for therapy in aggressive human solid tumours.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Conference Flyer Page 1

Breast & Prostate Cancer half-day virtual conference: Saturday, September 18th, 2021

The What you Need to Know for Your Patients Post Breast & Prostate Cancer Conference, taking place online on Saturday, September 18th, 2021 from 8:00am – 1:30pm, is an accredited virtual half-day conference focusing on screening, treatment, side-effect management & emerging new therapies for breast & prostate cancer patients. Click here for more information and to register. 

Dr. Peter Black, team captain

Terry Fox Run fundraiser: September 19th, 2021

The 41st Annual Terry Fox Run is taking place on Sunday September 19, 2021. If you are able, please consider donating to our team (tax receipts issued), raising funds for the Terry Fox Foundation's ground-breaking cancer research. 

Employment

Work at the Vancouver Prostate Centre

Wednesday, September 8, 2021

Recent publication proposes a potential new therapeutic approach to treatment-resistant prostate cancer

Tuesday, August 3, 2021

Dr. Cherkasov receives 2021 Faculty of Medicine Distinguished Achievement Award

Dr. Cherkasov