Major Research Programs

Vancouver Prostate Centre investigators are involved in large translational research programs with numerous internal and external collaborators. Some of these key programs include:

Integrating key components of translational cancer research, PC-TRiADD aims to discover molecular mechanisms of cancer therapeutic resistance; use this knowledge to discover new patent-protected drug products and biomarkers; develop new services and products; improve cancer outcomes; and promote regional growth for biotechnology. This program was funded by the Centres of Excellence for Commercialization and Research for 11 years.

Our Terry Fox Research Institute (TFRI)-funded program of six highly integrated projects spans the research spectrum from discovery to treatment, with the overall objective of elucidating genomic and molecular mechanisms driving castrate-resistant prostate cancer and using this knowledge to develop new therapies targeting biologically relevant pathways in order to prolong disease control.

The VPC’s capacities for drug discovery via structural biology have recently been expanded via a Canadian Foundation for Innovation (CFI) Infrastructure grant and a Canada Excellence Research Chair (CERC) in Precision Cancer Drug Design (PCDD). This program aims, over seven years, to revolutionize the way we discover novel anti-cancer drugs, assisted by use of companion genomic biomarkers in a precision oncology framework.  In response to the global COVID-19 pandemic, the novel AI-based platform, Deep Docking, is being used as the first step in the translational research pipeline towards finding the top candidate compounds for effective antiviral therapeutics.  The in silico results will proceed through our well-established translational research pipeline from bench to bedside.

This clinical research program, made possible by Canadian Foundation for Innovation (CFI) and a generous donation by a private donor, is working towards better delivery of personalized therapeutics to patients with advanced or treatment-resistant cancer of the prostate, kidney or bladder.

The Dream Team’s program has the goal of improving the outcomes for men with metastatic castration-resistant prostate cancer (mCRPC) who are no longer responsive to current treatments by understanding the causes of resistance and developing new treatments to overcome them. Stand Up To Cancer (USA) and Prostate Cancer Foundation (USA) fund this highly collaborative team, consisting of a leader, co-leader, five principal investigators, two advocates and a project manager across nine research institutes. Click here for recent key publications

Working with three other world-class institutions and focused on curing cancer, the VPC’s current project centres on oncofetal glycosaminoglycans as molecular targets in prostate cancer. A Specialized Programs of Research Excellence (SPORE) grant is a prestigious award funded by the National Cancer Institute (USA) to promote collaborative, interdisciplinary translational cancer research.

 

Updated  March 27, 2020

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

VPC Terry Fox team 2016

Terry Fox Run - September 20, 2020

The 40th annual Terry Fox Run takes place on Sunday September 20 across Canada, as a virtual event.  Please consider donating to or joining our TFRI-VPC team as we raise funds to enable The Terry Fox Foundation & The Terry Fox Research Institute to continue their support of innovative and progressive cancer research programs

Employment

Work at the Vancouver Prostate Centre

Thursday, September 24, 2020

Drs. Gleave, Lack and Wang awarded CIHR Project Grants

Tuesday, September 8, 2020

MSFHR 2020 Awardees: Drs. Hach, Gentile, Massah

Thursday, June 25, 2020

Drs. Cherkasov and Jean receive CIHR grant to find new antiviral drugs to treat COVID-19