Blood-based tumour profiling provides less-invasive option for treatment-resistant prostate cancer

Date Posted: 
2017-06-29

The Journal of the National Cancer Institute today published a landmark multi-institutional study describing the first comprehensive comparison of blood-based tumour biopsy versus metastatic tissue biopsy for lethal prostate cancer.

Led by Vancouver Prostate Centre PIs Wyatt, Chi and Gleave, this study showed that a blood-based test can identify all the important driver mutations that are detected in a tissue biopsy. This paves the way for blood-based tumour profiling to replace the need for the metastatic tissue biopsy in prostate cancer patients with treatment-resistant disease.

The work was funded by a Stand Up to Cancer Prostate Cancer Foundation Prostate Dream Team Translational Cancer Research Grant, with additional support provided by Prostate Cancer Canada through the Movember Rising Star in Prostate Cancer research program (AW), the Emil Aaltonen Foundation (MA), and a Terry Fox New Frontiers Program Project.

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer 
Alexander W. Wyatt, Matti Annala, Rahul Aggarwal, Kevin Beja, Felix Feng, Jack Youngren, Adam Foye, Paul Lloyd, Matti Nykter, Tomasz M. Beer, Joshi J. Alumkal, George V. Thomas, Robert E. Reiter, Matthew B. Rettig, Christopher P. Evans, Allen C. Gao, Kim N. Chi, Eric J. Small, Martin E. Gleave

 

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Events

Rock4Prostate

Rock4Prostate fundraiser - Friday Nov 8, 2019

The 2nd annual Rock4Prostate event takes place Friday Nov 8 at the Backstage Lounge Pub on Granville Island.  Tickets available at Eventbrite and at the door ($20 or $10 for students 19+), with proceeds going to Prostate Cancer Canada.  Please visit the Facebook event page for more details

VPC Movember 2013 team

Movember fundraiser: Nov. 1 - 30, 2019

Movember is an international charity raising funds for men's health initiatives. Movember Canada focuses on prostate cancer, testicular cancer, mental health and suicide prevention. Please visit moteam.co/the-vancouver-prostate-centre to join or donate to our Centre's Movember fundraising team.

Employment

Work at the Vancouver Prostate Centre

Monday, September 16, 2019

Drs Cox, Gleave and Goldenberg awarded Prostate Cancer Canada and Movember 2019 Discovery Grants

Drs Cox, Gleave and Goldenberg
Thursday, September 12, 2019

Drs. Wyatt and Sorensen receive 2019 UBC Faculty of Medicine Awards for Distinguished Achievement

Drs Wyatt and Sorensen
Tuesday, September 10, 2019

Drs. Sorensen, Ester and Huntsman elected to Royal Society of Canada

Drs Sorensen, Ester, Huntsman