Blood-based tumour profiling provides less-invasive option for treatment-resistant prostate cancer

Date Posted: 
2017-06-29

The Journal of the National Cancer Institute today published a landmark multi-institutional study describing the first comprehensive comparison of blood-based tumour biopsy versus metastatic tissue biopsy for lethal prostate cancer.

Led by Vancouver Prostate Centre PIs Wyatt, Chi and Gleave, this study showed that a blood-based test can identify all the important driver mutations that are detected in a tissue biopsy. This paves the way for blood-based tumour profiling to replace the need for the metastatic tissue biopsy in prostate cancer patients with treatment-resistant disease.

The work was funded by a Stand Up to Cancer Prostate Cancer Foundation Prostate Dream Team Translational Cancer Research Grant, with additional support provided by Prostate Cancer Canada through the Movember Rising Star in Prostate Cancer research program (AW), the Emil Aaltonen Foundation (MA), and a Terry Fox New Frontiers Program Project.

Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer 
Alexander W. Wyatt, Matti Annala, Rahul Aggarwal, Kevin Beja, Felix Feng, Jack Youngren, Adam Foye, Paul Lloyd, Matti Nykter, Tomasz M. Beer, Joshi J. Alumkal, George V. Thomas, Robert E. Reiter, Matthew B. Rettig, Christopher P. Evans, Allen C. Gao, Kim N. Chi, Eric J. Small, Martin E. Gleave

 

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

10th Anniversary Ride to Live

West Coast Motorcycle Ride To Live: May 26th

The 10th Anniversary West Coast Motorcycle Ride to Live is taking place in Vancouver and the Fraser Valley on May 26 (Victoria date to be finalized), with details on the event and how to register on the event website.  This fundraiser for Prostate Cancer Foundation BC includes a 50/50 raffle open to all BC residents over age 19.

Step  Up Challenge 2019

Step Up Challenge Vancouver - March 10, 2019

Donations are still being accepted for Prostate Cancer Canada's Step Up Challenge fundraiser, which took place on Sunday March 10.   Click here to donate to The Vancouver Prostate Centre team

Employment

Work at the Vancouver Prostate Centre

Thursday, April 18, 2019

Dr. Subramaniam joins UBC as Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design

Dr. Subramaniam
Monday, April 1, 2019

VPC's translational research profiled in UBC Faculty of Medicine News

Dr. Gleave at the VPC