Dr. Dong interviewed for Science in the City Publication of the Week

Date Posted: 
2019-04-10
Dr. Xuesen Dong

A recent publication from Dr Xuesen Dong and team is featured as Science in the City's Publication of the Week. "RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression" was published in European Urology.

The results in this publication provide insights on designing future therapeutic strategies to control neuroendocrine prostate cancer (NEPC)  development and progression. Specifically, this study defines the molecular mechanism by which the RNA splicing factor SRRM4 modulates RNA splicing of the histone demethylase BHC80 to confer cancer cells growth advantages and promote NEPC progression. It links RNA splicing and epigenetic modification of histones that can trigger the immune responses of tumour cells to induce multiple tumour promoting cytokines. Having shown that the major downstream effector of SRRM4-BH80 axis involves MyD88 signalling, the publication provides proof-of-principle evidence that MyD88 inhibitors can suppress the growth of NEPC spheroids and xenografts.

This research was supported by the CIHR, Prostate Cancer Canada, the Terry Fox Research Institute and NIH Prostate Cancer SPORE.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Terry Fox

Terry Fox Run - September 15, 2019

This year's Terry Fox Run takes place on Sunday September 15, in locations across Canada.  Please consider donating to or joining our TFRI-VPC team as we raise funds to enable The Terry Fox Foundation & The Terry Fox Research Institute to continue their support of innovative and progressive cancer research programs

Employment

Work at the Vancouver Prostate Centre

Monday, September 16, 2019

Drs Cox, Gleave and Goldenberg awarded Prostate Cancer Canada and Movember 2019 Discovery Grants

Drs Cox, Gleave and Goldenberg
Thursday, September 12, 2019

Drs. Wyatt and Sorensen receive 2019 UBC Faculty of Medicine Awards for Distinguished Achievement

Drs Wyatt and Sorensen
Tuesday, September 10, 2019

Drs. Sorensen, Ester and Huntsman elected to Royal Society of Canada

Drs Sorensen, Ester, Huntsman