Dr. Dong interviewed for Science in the City Publication of the Week

Date Posted: 
2019-04-10
Dr. Xuesen Dong

A recent publication from Dr Xuesen Dong and team is featured as Science in the City's Publication of the Week. "RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression" was published in European Urology.

The results in this publication provide insights on designing future therapeutic strategies to control neuroendocrine prostate cancer (NEPC)  development and progression. Specifically, this study defines the molecular mechanism by which the RNA splicing factor SRRM4 modulates RNA splicing of the histone demethylase BHC80 to confer cancer cells growth advantages and promote NEPC progression. It links RNA splicing and epigenetic modification of histones that can trigger the immune responses of tumour cells to induce multiple tumour promoting cytokines. Having shown that the major downstream effector of SRRM4-BH80 axis involves MyD88 signalling, the publication provides proof-of-principle evidence that MyD88 inhibitors can suppress the growth of NEPC spheroids and xenografts.

This research was supported by the CIHR, Prostate Cancer Canada, the Terry Fox Research Institute and NIH Prostate Cancer SPORE.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

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Breast & Prostate Cancer half-day virtual conference: Saturday, September 18th, 2021

The What you Need to Know for Your Patients Post Breast & Prostate Cancer Conference, taking place online on Saturday, September 18th, 2021 from 8:00am – 1:30pm, is an accredited virtual half-day conference focusing on screening, treatment, side-effect management & emerging new therapies for breast & prostate cancer patients. Click here for more information and to register. 

Dr. Peter Black, team captain

Terry Fox Run fundraiser: September 19th, 2021

The 41st Annual Terry Fox Run is taking place on Sunday September 19, 2021. If you are able, please consider donating to our team (tax receipts issued), raising funds for the Terry Fox Foundation's ground-breaking cancer research. 

Employment

Work at the Vancouver Prostate Centre

Wednesday, September 8, 2021

Recent publication proposes a potential new therapeutic approach to treatment-resistant prostate cancer

Tuesday, August 3, 2021

Dr. Cherkasov receives 2021 Faculty of Medicine Distinguished Achievement Award

Dr. Cherkasov