Novel, Highly Specific Therapeutic Target for Neuroendocrine Prostate Cancer Identified by VPC Scientists

Date Posted: 
2015-07-30

Drs. Akamatsu, Wyatt, Gleave and Collins and their team at the VPC have published the result of their ground-breaking work identifying a gene called PEG10 as a novel and highly-specific therapeutic target for neuroendocrine prostate cancer (NEPC) ("The placental gene PEG10 promotes progression of neuroendocrine prostate cancer", Cell Reports, published online).

NEPC is the most common form of prostate cancer that does not rely on the androgen receptor. There are few treatments for NEPC, and due to its fast growth rate and ability to metastasize, patient life expectancy after NEPC diagnosis is short. NEPC can evolve from typical prostate cancer by an adaptive response of the cancer cells while under the stress of treatment.

The team studied this adaptive response and identified key genes that were associated with the malignant aspects of clinical NEPC. One of the genes with increased expression, PEG10, is a gene that is normally only 'switched-on' during the development of the placenta. When PEG10 is aberrantly switched-on again early during NEPC development, it increases proliferation of cancer cells and promotes metastasis. Blocking PEG10 activity in model systems resulted in reduced tumor growth and restricted invasion of the surrounding normal tissue.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Rock4Prostate

Rock4Prostate fundraiser - Friday Nov 8, 2019

The 2nd annual Rock4Prostate event takes place Friday Nov 8 at the Backstage Lounge Pub on Granville Island.  Tickets available at Eventbrite and at the door ($20 or $10 for students 19+), with proceeds going to Prostate Cancer Canada.  Please visit the Facebook event page for more details

VPC Movember 2013 team

Movember fundraiser: Nov. 1 - 30, 2019

Movember is an international charity raising funds for men's health initiatives. Movember Canada focuses on prostate cancer, testicular cancer, mental health and suicide prevention. Please visit moteam.co/the-vancouver-prostate-centre to join or donate to our Centre's Movember fundraising team.

Employment

Work at the Vancouver Prostate Centre

Monday, September 16, 2019

Drs Cox, Gleave and Goldenberg awarded Prostate Cancer Canada and Movember 2019 Discovery Grants

Drs Cox, Gleave and Goldenberg
Thursday, September 12, 2019

Drs. Wyatt and Sorensen receive 2019 UBC Faculty of Medicine Awards for Distinguished Achievement

Drs Wyatt and Sorensen
Tuesday, September 10, 2019

Drs. Sorensen, Ester and Huntsman elected to Royal Society of Canada

Drs Sorensen, Ester, Huntsman