Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer: Dr. Daugaard

Date Posted: 

Lineage plasticity of prostate cancer is associated with resistance to androgen receptor (AR) pathway inhibition (ARPI) and supported by a reactive tumor microenvironment. According to research published in the open access journal nature communications, changes in chondroitin sulfate (CS), a major glycosaminoglycan component of the tumor cell glycocalyx and extracellular matrix, is AR-regulated and promotes the adaptive progression of castration-resistant prostate cancer (CRPC) after ARPI. AR directly represses transcription of the 4-O-sulfotransferase gene CHST11 under basal androgen conditions, maintaining steady-state CS in prostate adenocarcinomas. When AR signaling is inhibited by ARPI or lost during progression to non-AR-driven CRPC as a consequence of lineage plasticity, CHST11 expression is unleashed, leading to elevated 4-O-sulfated chondroitin levels. Inhibition of the tumor cell CS glycocalyx delays CRPC progression, and impairs growth and motility of prostate cancer after ARPI. Thus, a reactive CS glycocalyx supports adaptive survival and treatment resistance after ARPI, representing a therapeutic opportunity in patients with advanced prostate cancer.

Dr. Mads Daugaard and Research Scientist Dr Nader Al-Nakouzi, with other researchers from Vancouver Prostate Centre, collaborated with the University of Washington, Seattle, and the Pacific Northwest Prostate Cancer SPORE for this study.



A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.


It's a Snow Day!

Hitting the slopes early 2023 and support
Prostate Cancer here in BC!

Visit the website to Register: Prostate Cancer | It's A Snow Day | Surrey (

Pars for Prostate fundraiser: September 22, 2022

The First Annual Pars for Prostate golf fundraiser in support of Prostate Cancer Foundation BC takes place September 22, 2022 at Westwood Plateau Golf Course. For information and to register please visit


Work at the Vancouver Prostate Centre

Tuesday, November 29, 2022

Congratulations to the Vancouver Prostate Centre team on receiving a 2022 team grant from the Terry Fox Research Institute

Tuesday, November 15, 2022

Dr. Gleave received the Mostafa M. Elhilali Award