Expertise & Services

Expertise

The Laboratory for Advanced Genome Analysis offers competitive service prices based on a cost-recovery, not-for-profit model. We specialize in the acquisition, processing, statistical analysis, integration, and visualization of high-density sequencing and microarray data. Projects have access to state-of-the-art equipment, software and highly trained personnel to generate and analyze complex data and offer important recommendations. LAGA prides itself on providing solutions that are economical and personalized.

LAGA offers unique capabilities in the following areas:

  • Translational genomics, where genomics, computer science, and clinical science converge in diagnostics and therapeutics
  • Combined use of microarray and sequencing technologies with solutions for challenging clinical samples like formalin-fixed, paraffin embedded and plasma biospecimens
  • Project-tailored downstream bioinformatics analysis and data visualization
  • Comparative oncogenomics, where tumors from different organ sites converge on common genome structures as they progress toward metastasis

Services

LAGA supports the supports small and large-scale projects across Canada and internationally for the following applications. See Table 1 below for additional information:

Next Generation Sequencing

  • Exome sequencing for integrative analysis of SNVs and CNVs
  • RNA sequencing for gene expression analysis
  • RNA sequencing for whole transcriptome analysis             
  • Targeted DNA and RNA sequencing
  • ChIP-seq; ATAC-seq        
  • 16S rRNA genes
  • Small RNA sequencing  

Microarray (main applications)

  • Gene expression analysis
  • CNV analysis

Sequencing platforms and applications

Bioinformatic Analysis

  • Acquisition, processing, statistical analysis, integration, and visualization of high-density genomic and transcriptome data from simple to complex experimental designs using one of several platforms
  • Utilization of software that allows seamless cross-platform integration and analysis of expression, genomic, and next generations sequence data making possible extremely powerful and comprehensive studies

Computing Infrastructure

For data analysis, we use a cluster of 28 nodes, each with 2x Intel Xeon Gold 6130 16C 2.1GHz processor, 768GB RAM, with 896 cores, and 2Pb of storage. We also have access to an older cluster with 0.5 Pb of storage, 70 nodes, each with 2x Xeon 6C X5650 2.66GHz, 192Gb RAM, with 840 cores.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Terry Fox

Terry Fox Run - September 15, 2019

This year's Terry Fox Run takes place on Sunday September 15, in locations across Canada.  Please consider donating to or joining our TFRI-VPC team as we raise funds to enable The Terry Fox Foundation & The Terry Fox Research Institute to continue their support of innovative and progressive cancer research programs

Employment

Work at the Vancouver Prostate Centre

Monday, September 16, 2019

Drs Cox, Gleave and Goldenberg awarded Prostate Cancer Canada and Movember 2019 Discovery Grants

Drs Cox, Gleave and Goldenberg
Thursday, September 12, 2019

Drs. Wyatt and Sorensen receive 2019 UBC Faculty of Medicine Awards for Distinguished Achievement

Drs Wyatt and Sorensen
Tuesday, September 10, 2019

Drs. Sorensen, Ester and Huntsman elected to Royal Society of Canada

Drs Sorensen, Ester, Huntsman