Expertise & Services

Expertise

The Laboratory for Advanced Genome Analysis offers competitive service prices based on a cost-recovery, not-for-profit model. We specialize in the acquisition, processing, statistical analysis, integration, and visualization of high-density sequencing and microarray data. Projects have access to state-of-the-art equipment, software and highly trained personnel to generate and analyze complex data and offer important recommendations. LAGA prides itself on providing solutions that are economical and personalized.

LAGA offers unique capabilities in the following areas:

  • Translational genomics, where genomics, computer science, and clinical science converge in diagnostics and therapeutics
  • Combined use of microarray and sequencing technologies with solutions for challenging clinical samples like formalin-fixed, paraffin embedded and plasma biospecimens
  • Project-tailored downstream bioinformatics analysis and data visualization
  • Comparative oncogenomics, where tumors from different organ sites converge on common genome structures as they progress toward metastasis

Services

LAGA supports the supports small and large-scale projects across Canada and internationally for the following applications. See Table 1 below for additional information:

Next Generation Sequencing

  • Exome sequencing for integrative analysis of SNVs and CNVs
  • RNA sequencing for gene expression analysis
  • RNA sequencing for whole transcriptome analysis             
  • Targeted DNA and RNA sequencing
  • ChIP-seq; ATAC-seq        
  • 16S rRNA genes
  • Small RNA sequencing  

Microarray (main applications)

  • Gene expression analysis
  • CNV analysis

Sequencing platforms and applications

Bioinformatic Analysis

  • Acquisition, processing, statistical analysis, integration, and visualization of high-density genomic and transcriptome data from simple to complex experimental designs using one of several platforms
  • Utilization of software that allows seamless cross-platform integration and analysis of expression, genomic, and next generations sequence data making possible extremely powerful and comprehensive studies

Computing Infrastructure

For data analysis, we use a cluster of 28 nodes, each with 2x Intel Xeon Gold 6130 16C 2.1GHz processor, 768GB RAM, with 896 cores, and 2Pb of storage. We also have access to an older cluster with 0.5 Pb of storage, 70 nodes, each with 2x Xeon 6C X5650 2.66GHz, 192Gb RAM, with 840 cores.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Plaid for Dad

Plaid for Dad Fundraiser, June 14, 2019

Plaid for Dad is a workplace fundraiser for Prostate Cancer Canada, with online registration & fundraising leading up to Friday June 14th's "wear plaid to work" day. Visit the event website to register a team, join/fundraise for a team or buy plaid to wear on the day.      

Fathers Day Walk Run 2019

Raymond James Father's Day Walk Run Fundraiser, June 16, 2019

The 21st Annual Raymond James Walk Run fundraiser for Prostate Cancer Foundation BC takes place on Sunday June 16, 2019 in various locations across BC. Registration fees ($40) include a shirt and BBQ lunch, and are waived for those who raise over $150. Click here to sponsor our Centre's team (opens in new window).

 

Employment

Work at the Vancouver Prostate Centre

Friday, May 3, 2019

Dr. Mads Daugaard receives the St. Baldrick’s Foundation Robert J. Arceci Innovation Award

Dr. Daugaard
Thursday, April 18, 2019

Dr. Subramaniam joins UBC as Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design

Dr. Subramaniam
Monday, April 1, 2019

VPC's translational research profiled in UBC Faculty of Medicine News

Dr. Gleave at the VPC