Expertise & Services

Our core facility specializes in the generation, processing, statistical analysis, integration, and visualization of high-density genomics and proteomics data for translational research. 

Laboratory expertise includes:

  • Experimental design
  • Sample preparation (e.g. DNA/RNA extraction and quality control)
  • Library preparation and enrichment for bulk DNA and RNA sequencing (does not differentiate among cell types within the sample)
  • Single-cell RNA sequencing
  • Protein quantification by liquid chromatography-mass spectrometry
  • Analytical pharmacology
  • Pilot projects to evaluate technology performance
  • Training and use of instruments

Data analysis expertise includes tailored bioinformatics support:

  • Use of discrete algorithms
  • Statistical analysis
  • The computational workflows to perform single-omic and integrated analyses of genomic, transcriptomic and proteomic data.
  • High-throughput data analysis is done on a high-performance cluster system.

Supported applications

  • 10x Genomics single-cell sequencing
  • Exome sequencing for integrative analysis of SNVs and CNVs
  • mRNA sequencing for gene expression or whole transcriptome analysis
  • Targeted DNA and RNA sequencing
  • Small RNA sequencing
  • NGS library sequencing
  • Qualitative (label-free) and quantitative (TMT, SILAC) differential analysis of protein levels
  • Analytical chemistry and clinical pharmacology

Major equipment

  • Maxwell RSC for automated DNA and RNA extraction system
  • Agilent TapeStation 4200 for quality control of DNA and RNA
  • Covaris M220 focused-ultrasonicator for sample preparation
  • ThermoFisher Zephyr NGS liquid handler systems for automated preparation of NGS sequencing libraries
  • Illumina NextSeq, MiSeq, MiniSeq
  • nanoLC Orbitrap Lumos, standard LC triple quad, standard LC with photometric detection for LC-MSMS
  • Computing infrastructure: 28 nodes / 896 cores / 2Pb of storage

 

Updated November 27, 2020

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Pars for Prostate fundraiser: September 22, 2022

The First Annual Pars for Prostate golf fundraiser in support of Prostate Cancer Foundation BC takes place September 22, 2022 at Westwood Plateau Golf Course. For information and to register please visit www.parsforprostate.ca

Dr. Black

Terry Fox Run fundraiser: September 18th, 2022

The 42nd Annual Terry Fox Run is taking place on Sunday September 18, 2022. If you are able, please consider joining and/or donating to our team (tax receipts issued), raising funds for the Terry Fox Foundation's ground-breaking cancer research

Employment

Work at the Vancouver Prostate Centre

Tuesday, September 20, 2022

Dr Mads Daugaard develops an AI cell analytics app which could supercharge biotechnology research

Wednesday, July 20, 2022

With just a tablespoon of blood, B.C. researchers aim to transform cancer treatment