Expertise & Services

Expertise

Our Functional Genomics core has proven expertise in designing experiments to develop and test pre-clinical treatment strategies using validated models that recapitulate human biology. Model systems are used for validation of novel therapeutics designed to target genetic and molecular aberrations associated with aggressive prostate cancer that are identified using next-generation sequencing in human tumour and circulating free DNA samples.

Services

The Functional Genomics Core provides valuable tools with high clinical relevance for studying the molecular and cellular development and progression of prostate cancer, including:

  • Rapid and comprehensive evaluation of novel small molecules and biologics in preclinical model systems including:
    • Cytotoxicity assays
    • Clonogenic assays
    • Biomarker assays (established or novel)
    • Drug-target and off-target interaction assays
    • Drug-drug interactions
    • in vitro and in vivo tumour cell lines
  • An existing variety of cell lines and models (xenograft and transgenic) including:
    • models for disease progression from androgen dependent to castrate resistant prostate cancer
    • tumors/cells resistant to newly approved AR antagonist enzalutamide 
    • novel first-in-field neuroendocrine trans-differentiation patient-derived xenografts
  • Fully functioning suites for the generation and analysis of xenografts, transgenics and PDXs
  • Liquid nitrogen tanks for storage of patient and PDX tissue
  • Preparation and in vivo application of gene targeting techniques to test pre-clinical efficacy of novel anti-cancer agents, including:
    • antisense oligonucleotides (ASOs, siRNA)
    • novel small molecule or antibody inhibitors
    • novel combination therapies
  • Viral delivery for gain-of-function analyses
  • Antisense/RNAi/CRISPR-Cas9 technology for loss-of-function analyses

The Living Tumour Laboratory

The Living Tumor Lab is a unique and valuable resource, which grows a wide variety of patient-derived cancer tissues, including both low and high-grade solid cancers. This work enables researchers to readily study human cancer tissue in vivo, and develop a variety of transplantable tumour tissue lines that can be used as models for studying cancer growth/progression/metastasis and drug sensitivity.

For more information visit www.livingtumorlab.com

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

Rock4Prostate

Rock4Prostate fundraiser - Friday Nov 8, 2019

The 2nd annual Rock4Prostate event takes place Friday Nov 8 at the Backstage Lounge Pub on Granville Island.  Tickets available at Eventbrite and at the door ($20 or $10 for students 19+), with proceeds going to Prostate Cancer Canada.  Please visit the Facebook event page for more details

VPC Movember 2013 team

Movember fundraiser: Nov. 1 - 30, 2019

Movember is an international charity raising funds for men's health initiatives. Movember Canada focuses on prostate cancer, testicular cancer, mental health and suicide prevention. Please visit moteam.co/the-vancouver-prostate-centre to join or donate to our Centre's Movember fundraising team.

Employment

Work at the Vancouver Prostate Centre

Tuesday, November 19, 2019

Dr. Lallous appointed Senior Research Scientist, featured in VCH News

Dr. Lallous
Thursday, October 31, 2019

Dr. Zoubeidi promoted to Professor

Dr. Zoubeidi