Current Employment Opportunities

Critical funding from our research partners and donors has helped us to attract and retain the very best research talent from around the world, which in turn, increases our ability to move discoveries further along into clinical research and eventually treatments.

 

Date Posted: 
Tuesday, June 23, 2020

Postdoctoral Fellow, Dong Lab

The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a Postdoctoral Fellow, Dong Lab to join our research team.

The VPC has a large number of multi-disciplinary research programs in basic, clinic, and translational cancer research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

Dong Lab
The Postdoctoral Fellow will work under the supervision of Dr. Xuesen Dong, within a world-class multi-disciplinary team. Our research focuses on the mechanisms of therapy-resistant prostate cancers and the development of therapeutics to manage the disease (representative publications PMID: 32634132, 30910347, 27180064, 31819165). Ongoing projects include: 1) deciphering cancer stem cell signal pathways in regulating neuroendocrine prostate cancers and 2) circular RNA as diagnostic biomarkers of prostate cancers.

We are looking for multiple candidates to expand the existing projects aimed at understanding how Lin28 regulates stem cell network to counteract therapy-induced stress, and applying computer-aided drug design to develop Lin28 inhibitors. Candidates with a circular RNA research background are also welcome to join us.

Post-doctoral fellows will have opportunities to lead independent research projects, develop inter- and intra-laboratory collaborations, and publish in scientific journals. The successful candidates will have the opportunity to tackle cutting edge-problems in prostate cancer research, interact with world class scientists, and gain experiences and develop skillsets for his/her next career stage.

More information on Dr. Dong and his team can be found here: www.prostatecentre.com/about-us/people/dr-xuesen-dong.

Qualifications and Requirements

  • Relevant PhD degree in Molecular Biology, Biochemistry or Cell Biology.
  • Minimum five years related laboratory experience.
  • Demonstrated expertise with cell culture/transfection, western blotting, real time PCR and molecular cloning.
  • Experience with lenti-virus manipulation and animal work will be considered an asset.
  • Strong problem-solving skills.
  • Statistical data analysis and database management skills.
  • Excellent written/verbal communication skills and organizational skills
  • Demonstrated ability to work in a team environment.

Application Procedures
To apply for this position, please email careersatprostatecentre [dot] com with subject line Post-doctoral Research Fellow, Dong Lab with the following items attached:

  • Current CV
  • Cover letter

NOTE: Applications will be accepted until a qualified candidate is found. No telephone calls or drop-in inquiries accepted. Only those under consideration will be contacted.

Listing updated August 12, 2020

Date Posted: 
Thursday, June 25, 2020

Postdoctoral Fellow in Computational Chemistry (Machine Learning/COVID-19 Drug Discovery), Cherkasov Lab

The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a Postdoctoral Research Fellow in Computational Chemistry (Machine Learning/COVID-19 Drug Discovery to join Dr. Artem Cherkasov's research team.


The Vancouver Prostate Centre
VPC has a large, multi-disciplinary research program that undertakes basic, clinic, and translational research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

Cherkasov Lab
Professor Artem Cherkasov is looking for a talented Postdoctoral Research Fellow with a demonstrated research background in machine learning to join his computer-aided drug design group. The Postdoctoral Fellow will work on exciting drug discovery programs providing cutting-edge deep learning docking strategy --"Deep Docking"--to support structure-based and ligand-based virtual screening and lead optimization for SARS-COV-2 antivirals. Dr. Cherkasov (Professor, University of British Columbia) has recently been awarded four COVID-19 Rapid Response Grants and is collaborating with advanced computing companies to deploy machine learning to virtually screen 50B+ compounds for multiple COVID-19 therapeutic targets.

More information on Dr. Cherkasov and his team can be found here: www.prostatecentre.com/about-us/people/dr-art-cherkasov.

Qualifications and Requirements

  • PhD in Computational Chemistry or Computational Biochemistry.
  • Excellent problem solving and communication skills.
  • Research experience in developing machine learning methods for life science.
  • Strong Deep-learning programming experience with GPUs.
  • Statistical data analysis and database management skills.
  • Demonstrated experience using various programming languages including Python, BASH, Perl, AWK, and SVL.
  • Well-developed portfolio of open-source software available on GitHub
  • Solid background in computational chemistry, biological chemistry, organic chemistry, medicinal chemistry and pharmacokinetics.
  • Practical experience in structure-based and ligand-based drug design and compound library design.
  • Familiarity with state-of-the-art modeling and cheminformatics tools such as Molecular Operating Environment (MOE), Schrödinger, and OpenEye suite of programs.

Duties

  • Work with Dr. Cherkasov and collaborators to develop and/or apply cutting-edge computational approaches--Deep Docking--to screen 50B+ compounds for multiple SARS-CoV-2 viral targets.
  • Reading published papers and adapting procedures accordingly.
  • Liaising with collaborators and presenting research findings at international conferences.
  • Preparing manuscripts for submission to high impact journals.
  • Assisting with the creation of research proposals to be submitted to granting agencies.

Application Procedures
To apply for this position, please email careersatprostatecentre [dot] com with subject line Postdoctoral Research Fellow, Cherkasov Lab with the following items attached:

  • Current CV
  • Cover letter

NOTE: No telephone calls or drop-in inquiries accepted. Only those under consideration will be contacted.

Date Posted: 
Monday, October 26, 2020

Laboratory Research Assistant, Daugaard Lab

The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a temporary, full-time Laboratory Research Assistant to join Dr. Mads Daugaard’s research team.

The Vancouver Prostate Centre
VPC has a large, multi-disciplinary research program that undertakes basic, clinic, and translational research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

Daugaard Lab
The Daugaard laboratory focuses on innovative research in molecular cancer biology developing biotechnology for diagnostic and therapeutic use in different cancer indications. The successful applicant will work in a multi-disciplinary research team with access to state-of-the-art equipment and facilities in collaboration with national and international research groups and pharmaceutical companies. More information on Dr. Daugaard and his team can be found here: http://www.prostatecentre.com/about-us/people/dr-mads-daugaard.

Project description
The successful applicant will be part of an exciting project on characterization and development of novel experimental bi-specific immune cell engagers based on VAR2 technology (Cancer Cell, 2015; European Urology, 2017; Cells, 2020) targeting a distinct oncofetal glycosaminoglycan modification to proteoglycans (oncofetal chondroitin sulfate, ofCS) expressed in solid tumors. The project is meant to support IND-enabling of VAR2 bi-specifics for clinical trial within 1-2 years. The successful applicant will be expected to perform in vivo experiments to support the project.

Responsibilities

  • Follow tutorial documents, procedures, methods and study protocols to provide a proficient level of support for in vivo studies.
  • Develop technical competence and proficiency with in vivo methods (e.g., dosing, sample collection, monitoring) and lab procedures.
  • Implement data management and documentation practices.
  • Able to work with frequent direction and supervision and seek assistance when needed.
  • Establish effective work relationships within group and participate in teams.
  • Collaborate with management, peers and research partners to support in vivo studies.
  • Follow verbal and written instructions and exhibit social skills that are conducive to effective communication and that contribute to a collaborative work environment.

Qualifications and Experience

  • BA or higher in biochemistry, biology, biomedical engineering, molecular biology or similar field.
  • 2-3 years of hands-on in vivo tumor experiment experience required.
  • Cell culture experience strongly preferred.
  • Flow cytometry experience desired.
  • Understanding of cancer biology and immunology.
  • Proven ability to work independently.
  • Strong problem-solving skills.
  • Excellent written and verbal communication skills.
  • Friendly, organized, and detail-oriented team player.
  • Willing and able to work occasional weekends and statutory holidays.

Compensation
The starting salary range for this position is $50,000 to $55,000 per annum.

Preferred start date
December 2020.

Application Procedures
To join our team, please email careersatprostatecentre [dot] com with subject line Laboratory Research Assistant, Daugaard Lab with the following items attached:

  • Cover letter
  • Resume

Closing Date: We will commence reviewing applications November 6, 2020. No telephone calls or drop-in inquiries accepted. Only those under consideration will be contacted.

 

Date Posted: 
Friday, October 30, 2020

Research Associate, Lallous Lab (closes November 30)

The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a regular, full-time Research Associate to join the Gobind Khorana Protein Engineering Core under the direction of Dr. Nada Lallous.

The Vancouver Prostate Centre
VPC has a large, multi-disciplinary research program that undertakes basic, clinic, and translational research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

Lallous Lab
Our research focuses on the structural and biophysical characterization of important prostate/breast cancer and SARS-CoV-2 targets and the validation of novel therapies against those targets. The successful applicant is expected to develop and optimize biophysical methods for binding studies and drug validation.

Project description
Dr. Lallous is looking for a talented scientist to join the Gobind Khorana Protein Engineering Core. The successful candidate will work on the structural characterization of cancer targets and viral/host targets (e.g., SARS-CoV2) involved in disease progression. He/She will be in charge of developing and optimizing various biophysical assays to study protein/ligand interactions, managing equipment maintenance and booking/training new users, analyzing and reporting data and issuing invoices for the provided services.

More information on Dr. Lallous’s research can be found on the links below:
https://www.prostatecentre.com/about-us/people/dr-nada-lallous
https://www.prostatecentre.com/Gobind-Khorana-Protein-Engineering-Core

Responsibilities

  • Developing protocols for binding studies using ITC, MST, BLI and fluorescence based assays.
  • Characterizing proteins by MALS, thermal shift assay and DLS.
  • Implementing SOP and training protocols for new users.
  • Training and mentoring undergraduate and graduate students.
  • Solving technical problems with the equipment.
  • Helping in equipment evaluation and purchase.

Qualifications

  • PhD in Biochemistry or Structural Biology, or a MSc with advanced expertise in biophysics.
  • Strong expertise in protein expression and purification and use of AKTA systems.
  • Strong expertise in binding technologies such as BLI, ITC, MST, SPR. Prior experience with at least 2 of these methods is mandatory.
  • Strong expertise in protein quality control by DLS and MALS.
  • Ability to multitask and to work under strict deadlines.
  • Ability to manage multiple projects and continuously assess priorities.
  • Expertise in X-ray crystallography or cryo-EM is an asset.
  • Excellent written and verbal communication skills.
  • Excellent organizational and record keeping skills.
  • Friendly and respectful team player.

Application Procedures
To apply for this position, please email careersatprostatecentre [dot] com with subject line:

Research Associate, Lallous Lab with the following items attached:

  • Cover letter
  • Current CV

NOTE: Applications will be accepted until November 30, 2020. No telephone calls or drop-in inquiries accepted. Only those under consideration will be contacted.

Date Posted: 
Tuesday, December 1, 2020

Laboratory Research Assistant, Wyatt Lab

The Vancouver Prostate Centre (VPC) has an exceptional opportunity available for a regular, full-time or part-time (minimum 3 consecutive days) Laboratory Research Assistant to join Dr. Alexander Wyatt’s genomics and bioinformatics research team.

The Vancouver Prostate Centre
VPC has a large, multi-disciplinary research program that undertakes basic, clinic, and translational research. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research. It is affiliated with the University of British Columbia and the Vancouver Coastal Health Authority.

Wyatt Lab
Our laboratory studies the genomics of metastatic prostate and bladder cancers. Our primary research goals are to reveal the clinical relevance of specific molecular subtypes, and to develop minimally-invasive biomarkers for guiding therapy selection (i.e. precision oncology). We leverage innovative next-generation sequencing techniques and bioinformatics tools to interrogate tissue and liquid biopsies from patients enrolled on a series of ongoing clinical trials and protocols. We work very closely senior medical oncologists and urologists to ensure our research findings are translated to the clinic.

More information on Wyatt Lab is available at https://blogs.ubc.ca/wyattlab/

Responsibilities

  • Clinical sample receipt and processing
  • Biobank and database management
  • DNA library preparation and next-generation sequencing
  • Circulating cell-free DNA (cfDNA) assay development and standardization
  • Daily communication with clinical coordinators and physicians

Qualifications and Experience

  • B.Sc. or M.Sc. in Molecular Biology, Genetics, Biochemistry or a relevant field
  • At least one-year work experience in an academic or industrial lab setting, ideally in areas related to molecular biology, sample management and/or biobanking
  • Meticulous organizational and record keeping skills
  • Expertise with next-generation DNA sequencing
  • Excellent written and oral communication skills

Compensation
Salary range for this position is $48,834 to $75,853 per annum.

Application Procedures
To join our team, please email careersatprostatecentre [dot] com with subject line Laboratory Research Assistant, Wyatt Lab with the following items attached:

  • Cover letter
  • Resume

Closing Date: We will commence reviewing applications December 16, 2020. We thank all applicants for their interest. However, due to the high volume of applications received, only shortlisted candidates will be contacted. No phone calls or drop-in inquiries please.

A World Class Centre

The Vancouver Prostate Centre (VPC) has a track record of success that has earned it a reputation as one of the world’s most respected cancer facilities. It is a National Centre of Excellence and a designated Centre of Excellence for Commercialization and Research.

Events

VPC Terry Fox team 2016

Terry Fox Run - September 20, 2020

The 40th annual Terry Fox Run takes place on Sunday September 20 across Canada, as a virtual event.  Please consider donating to or joining our TFRI-VPC team as we raise funds to enable The Terry Fox Foundation & The Terry Fox Research Institute to continue their support of innovative and progressive cancer research programs

Employment

Work at the Vancouver Prostate Centre

Friday, November 6, 2020

Ninadh D’Costa awarded KCRNC-SOPER Foundation Grant

Ninadh D’Costa
Monday, November 2, 2020

Dr. Thaper awarded CDMRP Early Investigator Research Award

Dr. Daksh Thaper