Clinical Trials

What Is A Trial?

A clinical trial tests new treatments before they are available to patients through the mainstream market.  These new treatments are tested extensively, first in the laboratory and then in a series of studies called phase I, II and III clinical trials. These studies are done under very controlled conditions in order to determine if promising approaches to disease prevention, diagnosis, and treatment are safe and effective.

Types Of Clinical Trials

  • Treatment trials test new treatments (like a new drug, new approaches to surgery or radiation therapy, new combinations of treatments, or new methods such as gene therapy).
  • Prevention trials test new approaches, such as medicines, vitamins, minerals, or other supplements that doctors believe may lower the risk of disease.
  • Screening trials test the best way to find a disease such as cancer, especially in its early stages.

How Can I Be Referred?

By combining the genitourinary research programs at the Vancouver Prostate Centre and the BC Cancer Agency, clinical trial patients can participate in a full range of investigational studies. Patients interested in participating should contact their doctor for referral.

Trials Open to Enrollment

Clinical trials are run at the Vancouver Prostate Centre and at our partner institution, BC Cancer. To learn more about prostate cancer trials and other GU cancer trials visit the BC Cancer website. In addition, VCHRI has a searchable database of clinical trials at VCH.

A list of clinical trials that are currently recruiting patients at the Vancouver Prostate Centre are outlined below.  You can click on the links for detailed information where you’ll be taken to a registry federally and privately supported clinical trials conducted in Canada, the United States, and around the world. These websites give you information about a trial's purpose, who may participate, locations, and phone numbers for more details.

Note, this information should be used in conjunction with advice from health care professionals. Patients must be referred by their physician to be able to participate in a clinical trial.

Prostate Cancer

GUNS: Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer Study 
click here for more info

RADICAL-PC: a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer
click here for more info

Canary Prostate Active Surveillance Study (PASS)
click here for more info

Establishing the Clinical Utility of ClarityDX Prostate 
Click here for more info 

Ongoing, not recruiting patients:

PROTEUS: A Study of Apalutamide in Participants With High-risk, Localized or Locally Advanced Prostate Cancer Who Are Candidates for Radical Prostatectomy
click here for more info

A Phase III Multi-centre Open-label Randomized Controlled Trial of Multi-parametric Magnetic Resonance Imaging (MRI)-Targeted Biopsy Compared to Systematic Trans-rectal Ultrasound (TRUS) Guided Biopsy
click here for more info

A Randomized Phase III Study of Neo-Adjuvant Docetaxel and Androgen Deprivation Prior to Radical Prostatectomy Versus Immediate Radical Prostatectomy in Patients with High-Risk, Clinically Localized Prostate Cancer – NCIC CTG PRC.3/CALGB 90203
click here for more info

An International Prospective Open-Label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination with Standard of Care versus Standard of Care Alone in Adult Male Patients with Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
click here for more info

A Phase II, randomized, open-label, multi-center study of JSB462 (luxdegalutamide) in combination with abiraterone in adult male patients with metastatic hormone-sensitive prostate cancer.  
click here for more info

A randomized, double-blind, placebo-controlled, Phase 3 study of darolutamide plus androgen deprivation therapy (ADT) compared with placebo plus ADT in patients with high-risk biochemical recurrence (BCR) of prostate cancer. 
click here for more info

Bladder Cancer

A Phase II Clinical Study of Intravesical Photodynamic Therapy in Patients with BCG-Unresponsive Non-Muscle Invasive Bladder Cancer (NMIBC) or Patients Who Are Intolerant to BCG Therapy
click here for more info

Canadian Bladder Cancer Information System (CBCis)

A Phase 2/3 Multicenter Trial Evaluating the Safety and Efficacy of ST-02 on Ablation of Urothelial Carcinomas in the Upper Urinary Tract
click here for more info

A phase 1/2 study of EG-70 as an intravescial administration to patients with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC) and high-risk NMIBC patients who are BCG naïve or received incomplete BCG treatment.  
click here for more info

Active Surveillance versus definitive local therapy for patients showing clinical response following neoadjuvant therapy (Neoblast) 
click here for more info

The Role of the Urinary Microbiome in Determining Response to Intravesical BCG in Patients with High Risk Non-Muscle Invasive Bladder Cancer (RUMBLE)

A multicenter, randomized, double-blind, controlled phase III non-inferiority study assessing efficacy and safety of VERITY-BCG in management of intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) in BCG-naïve patients.  
click here for more info 

Kidney Cancer

Canadian Kidney Cancer Information System (CKCis) - a database project

Surveillance of Complex Renal Cysts – The SOCRATIC Study 
click here for more info 

Pelvic Surgery

ST-CP-201 is a Phase II, randomized, controlled, single-blind, single-center clinical trial evaluating the administration of up to 8 mL of ST-01 as a single-dose into the subcutaneous and fascia region of a surgical site and/or as nerve block
click here for more info

Erectile Dysfunction 

Phase 2 Clinical Trial of ST-04 Intraurethral Paste for Erectile Dysfunction  
click here for more info